Fifteen milligrams of PLGA were degraded in a 15-ml flask an
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Fifteen milligrams of PLGA were degraded in a 15-ml flask and 15 mg of phosphate buffer were added. The pH was monitored
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Fifteen milligrams of PLGA were degraded in a 15-ml flask and 15 mg of phosphate buffer were added. The pH was monitored with time and the results are depicted as follows (figure courtesy of Dr. J.W. Lee, University of Iowa, Iowa City, 2006): a. Calculate the concentration of acid if the pH dropped from 7.0 to 3 for a control specimen without buffer. b. Calculate the amount of buffer in milligrams needed to neutralize 1 mg of PLGA. c. Propose a mechanism of how the acids are being neutralized.
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